Therapeutic potential of bacteriocin like inhibitory substances against different disease conditions

Bacteriocins and Bacteriocin-like Substances.

Therapeutic potential of Paclitaxel against COVID-19

The coronavirus disease-2019(COVID-19) was reported in Wuhan, China, in late December 2019 and soon became the most serious global health challenge due to high rate of human-to-human transmission. The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), is a single-stranded RNA virus and belongs to the large Coronaviridae family. Paclitaxel, an antineoplastic drug extracted from the Tax...

In Vitro Evaluation of Bacteriocin-Like Inhibitory Substances Produced by Lactic Acid Bacteria Isolated During Traditional Sicilian Cheese Making

Bacteriocins are antimicrobial proteins produced by bacteria that inhibit the growth of other bacteria with a bactericidal or bacteriostatic mode of action. Many lactic acid bacteria (LAB) produce a high diversity of different bacteriocins. Bacteriocinogenic LAB are generally recognised as safe (GRAS) and useful to control the frequent development of pathogens and spoilage microorganisms. For t...

Prevention of streptococcal pharyngitis by anti-Streptococcus pyogenes bacteriocin-like inhibitory substances (BLIS) produced by Streptococcus salivarius.

BACKGROUND & OBJECTIVES Streptococcus salivarius is a numerically prominent member of the human oral microbiota that produces a variety of bacteriocin-like inhibitory substances (BLIS) having in vitro inhibitory activity against S. pyogenes. Our previous studies of S. salivarius isolates from children using a deferred antagonism BLIS production (P)-typing scheme showed that the 9 per cent of ch...

Bacteriocin-like substances produced by Lactococcus lactis subsp. lactis CF4MRS isolated from fish intestine: Antimicrobial activities and inhibitory properties

In the present study, evaluation of antimicrobial activities of Lactococcus lactis subsp. lactis CF4MRS bacteriocin-like substances (BLIS) against various fish pathogens was performed using an agar well diffusion assay. The cell-free supernatant (CFS) was first pre-treated using four different bioassays. In the first treatment T1, CFS was treated with catalase, and the pH was adjusted to 6.5 wi...